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Shinji Takai Selected Research

Alcoholic Fatty Liver

10/2020Chymase as a Possible Therapeutic Target for Amelioration of Non-Alcoholic Steatohepatitis.
1/2018Chymase Inhibitor as a Novel Therapeutic Agent for Non-alcoholic Steatohepatitis.
7/2017Chymase inhibitor prevents the development and progression of non-alcoholic steatohepatitis in rats fed a high-fat and high-cholesterol diet.
9/2013Chymase inhibitor ameliorates hepatic steatosis and fibrosis on established non-alcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.

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Shinji Takai Research Topics

Disease

27Fibrosis (Cirrhosis)
09/2023 - 11/2002
17Neoplasms (Cancer)
01/2024 - 02/2005
15Inflammation (Inflammations)
12/2022 - 02/2003
15Myocardial Infarction
03/2019 - 06/2002
12Hypertension (High Blood Pressure)
09/2019 - 10/2002
10Infections
12/2023 - 02/2003
10Atherosclerosis
03/2010 - 10/2002
10Hyperplasia
09/2007 - 11/2002
9Abdominal Aortic Aneurysm
01/2013 - 06/2004
8Cicatrix (Scar)
12/2019 - 05/2002
8Stroke (Strokes)
07/2017 - 07/2005
7Cardiovascular Diseases (Cardiovascular Disease)
12/2022 - 01/2004
6Retinal Perforations
02/2021 - 01/2006
6Glaucoma
12/2019 - 05/2002
6Liver Cirrhosis (Hepatic Cirrhosis)
09/2013 - 10/2006
5Aneurysm (Aneurysms)
02/2010 - 11/2002
4Pathologic Constriction (Stenosis)
01/2023 - 04/2005
4Epiretinal Membrane (Epiretinal Membranes)
02/2021 - 01/2015
4Diabetic Retinopathy (Retinopathy, Diabetic)
01/2021 - 01/2006
4Alcoholic Fatty Liver
10/2020 - 09/2013
4Neointima
05/2020 - 04/2005
4Non-alcoholic Fatty Liver Disease
05/2018 - 05/2010
4Allergic Conjunctivitis (Giant Papillary Conjunctivitis)
08/2013 - 06/2004
4Infarction (Infarctions)
10/2011 - 07/2002
4Cardiomyopathies (Cardiomyopathy)
04/2011 - 02/2002
4Hepatocellular Carcinoma (Hepatoma)
07/2008 - 11/2005
3Neoplasm Metastasis (Metastasis)
05/2023 - 01/2019
3Thrombosis (Thrombus)
01/2023 - 01/2008
3Aortic Aneurysm (Aneurysm, Aortic)
10/2022 - 11/2002
3Ischemia
10/2021 - 01/2004
3Body Weight (Weight, Body)
10/2020 - 03/2004
3Retinal Detachment (Retinal Detachments)
10/2020 - 01/2015
3Blister (Bulla)
12/2019 - 09/2011
3Wounds and Injuries (Trauma)
10/2018 - 05/2002
3Acute Liver Failure (Fulminant Hepatic Failure)
12/2015 - 06/2007
3Vascular Remodeling
08/2014 - 07/2005
3Vascular Diseases (Vascular Disease)
03/2005 - 08/2003
2Acquired Immunodeficiency Syndrome (AIDS)
04/2024 - 01/2002
2Patent Ductus Arteriosus
04/2024 - 12/2022
2Cataract (Cataracts)
10/2023 - 01/2015
2Tauopathies
08/2023 - 07/2021
2Staphylococcal Food Poisoning
07/2023 - 12/2020
2Rheumatoid Arthritis
10/2022 - 01/2012
2Pneumonia (Pneumonitis)
06/2022 - 03/2003
2Hypoxia (Hypoxemia)
12/2021 - 07/2009

Drug/Important Bio-Agent (IBA)

77Chymases (Chymase)IBA
04/2024 - 02/2002
33Angiotensin IIIBA
10/2023 - 10/2002
14Matrix Metalloproteinase 9 (Gelatinase B)IBA
01/2019 - 10/2004
14Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA
01/2013 - 02/2002
13Matrix Metalloproteinases (MMPs)IBA
10/2020 - 01/2006
12Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA
01/2013 - 02/2002
9NK3201IBA
07/2009 - 11/2002
8Tryptases (Tryptase)IBA
09/2023 - 06/2004
8CholesterolIBA
05/2018 - 10/2002
7EnzymesIBA
12/2023 - 02/2002
7Proteins (Proteins, Gene)FDA Link
10/2023 - 05/2007
6Angiotensin Receptor AntagonistsIBA
10/2023 - 07/2004
6TY 51469IBA
01/2023 - 08/2010
6Transforming Growth Factors (Transforming Growth Factor)IBA
10/2020 - 01/2008
6Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2014 - 11/2004
6AngiotensinsIBA
06/2012 - 02/2002
6Transforming Growth Factor beta (TGF-beta)IBA
11/2009 - 04/2003
5Biomarkers (Surrogate Marker)IBA
10/2021 - 02/2003
5candesartanIBA
01/2019 - 07/2006
5Valsartan (Vals)FDA Link
04/2013 - 12/2007
5acetamideIBA
02/2008 - 11/2002
4Peptide Hydrolases (Proteases)FDA Link
12/2022 - 12/2009
4Serine Proteases (Serine Protease)IBA
01/2021 - 01/2015
4Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA
09/2019 - 11/2005
4Eplerenone (Inspra)FDA LinkGeneric
09/2019 - 11/2005
4AldosteroneIBA
06/2012 - 11/2005
4CytokinesIBA
12/2009 - 11/2004
4HSP27 Heat-Shock ProteinsIBA
07/2008 - 11/2005
4Heat-Shock Proteins (Heat-Shock Protein)IBA
07/2008 - 06/2005
3CollagenIBA
09/2023 - 08/2009
3Proliferating Cell Nuclear Antigen (PCNA)IBA
11/2021 - 09/2011
3AntibodiesIBA
02/2021 - 01/2006
3Polytetrafluoroethylene (Teflon)FDA Link
05/2020 - 09/2007
3Mitomycin (Mitomycin-C)FDA LinkGeneric
12/2019 - 10/2009
3Reactive Oxygen Species (Oxygen Radicals)IBA
09/2019 - 10/2005
3Messenger RNA (mRNA)IBA
10/2018 - 04/2003
3HydrogelsIBA
05/2017 - 09/2011
3GelatinIBA
05/2017 - 09/2011
3LipopolysaccharidesIBA
12/2015 - 11/2012
3GalactosamineIBA
12/2015 - 06/2007
3Amlodipine (Norvasc)FDA LinkGeneric
04/2013 - 09/2010
3Pancreatic Elastase (Elastase)IBA
01/2013 - 06/2004
3p38 Mitogen-Activated Protein KinasesIBA
11/2009 - 06/2005
3olmesartanIBA
10/2009 - 10/2005
3trandolapril (Mavik)FDA LinkGeneric
05/2007 - 07/2002
2Tolonium ChlorideFDA Link
09/2023 - 05/2002
2Enterotoxins (Enterotoxin)IBA
07/2023 - 12/2020
2mast cell protease 4IBA
01/2023 - 01/2018
2Angiotensin IIBA
12/2022 - 08/2010
2CreatinineIBA
10/2021 - 06/2012

Therapy/Procedure

11Therapeutics
04/2024 - 11/2004
5Ligation
01/2023 - 05/2004
5Filtering Surgery
12/2019 - 05/2002
4Drug Therapy (Chemotherapy)
01/2020 - 02/2005
3Renal Dialysis (Hemodialysis)
05/2020 - 04/2005